Dimethyltryptamine (DMT)

Dimethyltryptamine (DMT)

 

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We present to you Dimethyltryptamine (DMT):

Dimethyltryptamine (DMT), also known as N,N-dimethyltryptamine, is a naturally occurring tryptamine and human neurotransmitter. Structurally, it is analogous to the neurotransmitter serotonin and other psychedelic tryptamines such as 5-MeO-DMT and 4-HO-DMT.

DMT is created in small amounts by the human body during normal metabolism[1] by the enzyme tryptamine-N-methyltransferase. Many cultures, indigenous and modern, ingest DMT as a psychedelic in extracted or synthesized forms. Pure DMT at room temperature is a clear or white to yellowish-red crystalline solid. DMT was first chemically synthesized in 1931.

Hallucinogenic properties:

DMT occurs naturally in many species of plants often in conjunction with its close chemical relatives 5-MeO-DMT and bufotenin (5-OH-DMT).[3] DMT containing plants are commonly used in several South American shamanic practices.

It is usually one of the main active constituents of the drink ayahuasca, however ayahuasca is sometimes brewed without plants that produce DMT. DMT occurs as the primary active alkaloid in several plants including such plants as Mimosa hostilis, Diplopterys cabrerana, and Psychotria viridis.

DMT is found as a minor alkaloid in snuff made from Virola bark resin in which 5-MeO-DMT is the main active alkaloid. DMT is also found as a minor alkaloid in the beans of Anadenanthera peregrina and Anadenanthera colubrina used to make Yopo and Vilca snuff in which bufotenin is the main active alkaloid.

DMT is generally not active orally unless it is combined with a monoamine oxidase inhibitor (MAOI), such as harmaline. Without an MAOI, the body quickly metabolizes orally-administered DMT, and it therefore has no hallucinogenic effect unless the dose exceeds monoamine oxidase’s metabolic capacity (very rare).

Other means of ingestion such as smoking or injecting the drug can produce powerful hallucinations and entheogenic activity for a short time (usually less than half an hour), as the DMT reaches the brain before it can be metabolised by the body’s natural monoamine oxidase. Taking a MAOI prior to smoking or injecting DMT will greatly prolong and potentiate the effects of DMT.

DMT is a powerful psychoactive substance. If DMT is smoked, injected, or orally ingested with an MAOI, it can produce powerful entheogenic experiences including intense visual hallucinations, euphoria, even true hallucinations (perceived extensions of reality).

Smoked: If DMT is smoked, the maximal effects last for a short period of time (5 to 30 minutes, dose-dependent). The onset after inhalation is very fast (less than 45 seconds) and maximal effects are reached within about a minute. The Business Man’s Trip is a common name because of the relatively short duration of vaporized, insufflated, or injected DMT.

Insufflation: When DMT is insufflated (snorted through the nostrils) the duration is markedly increased, and some users report diminished euphoria for increased “spiritual” qualities of effect.

Injection: Injected DMT produces an experience similar to inhalation in duration, intensity, and characteristics.

Oral ingestion: DMT, which is broken down by the digestive enzyme monoamine oxidase, is practically inactive if taken orally, unless combined with a monoamine oxidase inhibitor (MAOI).

The traditional South American ayahuasca, or yage, is a tea mixture containing DMT and a MAOI. There are a number of admixtures to this brew, but most commonly it is simply the leaves of Psychotria viridis (containing DMT), and the vine Banisteriopsis caapi (the source of MAOI).

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